Fig. 7: Lockdown is related to transient arrest of HER2.
From: Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization
a, b, c Transient arrest events (highlighted in red) within individual HER2 trajectories (top) determined from the confinement index calculated along a representative trajectory (bottom) upon treatment with OL4G (a), GL4G (b), and 6L1G (c). The threshold defining transient arrest events is indicated by the red line. d Identified fraction of confined particles. e Probability of transitioning into state of arrested diffusion. f Probability of mobilization out of arrested diffusion. Different colors in d–f indicate the three distinct groups of agents as described in Fig. 6 and referenced in the main text. The DARPins are shown schematically in Supplementary Fig. 1. Significance values for d–f are provided in Supplementary Fig. 8.
