Fig. 8: Putative mechanisms of HER2 lockdown and inhibition in the plasma membrane.
From: Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization
a Characteristic diffusion modes of HER2 monomers (cyan), dimers (red), and oligomers (green) induced by different agents are due to differential propensity of partitioning into membrane nanodomains. Schematic trajectories and transiently forming nanodomains integrated over time. Trajectory time resolution: ~5 ms; hop diffusion inflicted by the membrane skeleton omitted for clarity. Scale bar: 50 nm. b Efficient inhibition of HER2 by bipDARPins caused by arrest in an inactive conformation upon formation of daisy chains and by strongly enhanced partitioning of HER2 daisy chains into membrane nanodomains. Scale bar: 20 nm.
