Fig. 1: Residual analysis of thermal proteome profiling datasets.
From: A Bayesian semi-parametric model for thermal proteome profiling
A Scatter plots of residuals for the sigmoid model at different temperatures applied to the ATP dataset8. Orthogonal regression line shown in dark red and contours shown in yellow. Residuals are strongly correlated. B Sample Spearman correlation matrix of the residuals for the ATP dataset. C Example melting curves for some proteins from the ATP dataset. LOESS curves shown for visualisation. D as for (B), but for the Staurosporine dataset1. E Example melting curves from the Panobinostat dataset73. LOESS curves shown for visualisation. Concentration refers to Panobinostat concentration in μM.
