Fig. 2: Flp:shRNA parameter space highlights divergent performance of each topology. | Communications Biology

Fig. 2: Flp:shRNA parameter space highlights divergent performance of each topology.

From: Quantitative characterization of recombinase-based digitizer circuits enables predictable amplification of biological signals

Fig. 2

AUC (A), SNR (B), and fold change (C) heat maps highlight trends among each circuit topology. Outlined sections in the AUC and SNR heat maps represent topologies achieving AUC > 0.95 and SNR > 0 dB, respectively. Data represents the average of three technical replicates (n = 3) of circuits transiently transfected into HEK293FT cells 48 h after transfection/induction. Induced cell media contains 225 nM dox.

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