Fig. 4: Tissue and treatment-specific comparison between matched DEGs and DEPs.

a–d Venn plots showing the overlap (dark red) of differentially expressed genes (DEGs) for which their corresponding differentially expressed proteins (DEPs) were also identified in the (a) cortex during dehydration, (b) cortex during rehydration, (c) medulla during dehydration and (d) medulla during rehydration. The Venn plots also display the number of genes (blue) and proteins (light red) differentially expressed at either RNA or protein level only. e, f Gene Ontology (GO) networks displaying a subset of the most significantly enriched (p < 0.05) biological processes in the kidney cortex (e) and medulla (f) during dehydration. Two nodes are connected if they share 20% or more genes and thicker edges represent more overlapped genes, darker nodes are more significantly enriched gene sets and bigger nodes represent larger gene sets.