Fig. 1: Design and characterization of nanoparticles. | Communications Biology

Fig. 1: Design and characterization of nanoparticles.

From: Function-adaptive clustered nanoparticles reverse Streptococcus mutans dental biofilm and maintain microbiota balance

Fig. 1

a Schematic representation of the action of NPs as antibiofilm agents. The inherently antibiofilm CDots functionalized with phosphonium ions were encapsulated in a pH-responsive diblock copolymer. At low pH, the shell will open to release the therapeutic load leading to the eradication of the dental biofilm, the zoomed region represents the wrapping of smaller CDots in the diblock copolymer, the NP degradation is represented as faded particles; b transmission electron microscopic image of (i) bare CHX PR4+ NPs, (ii) and (iii) polymer-wrapped CDots (CHX PR4+ polymer NPs); c Hydrodynamic distribution of CHX PR4+ polymer NPs measured by ZetaView, arrows point to NPs; d hydrodynamic size stability over time; AFM height variation e before and f after wrapping the CHX PR4+ NPs in the polymer; g pH-dependent release profile.

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