Fig. 5: Different subtypes of interneurons carry different amounts of information in response to our synchrony encoding.

a Mutual information analysis of the average membrane potential of each cell type to our 1-bit signal within early (0–5 ms) response. Dotted lines indicate window of analysis, with greyed areas indicating what part of the response was analysed (One-way ANOVA, F(2,57) = 0.432, p = 0.656; post-hoc t-tests: GFP− vs. GIN+: t(35) = −0.830, p = 0.412; GAD67+ vs. GIN+: t(41) = −0.00, p = 0.988; GFP− vs. GAD67+: t(36) = −0.737, p = 0.473, * = tests significant at p ≤ 0.017 with Bonferroni correction). b Same analysis as (a) but restricting the analysis to only the later (5–50 ms) responses (One-way ANOVA, F(2,57) = 1.40, p = 0.244; post hoc t-tests: GFP− vs. GIN+: t(37) = −1.56, p = 0.127; GAD67+ vs. GIN+: t(41) = −0.809, p = 0.477; GFP− vs. GAD67+: t(36) = −0.933, p = 0.319; * = tests significant at p ≤ 0.017 with Bonferroni correction). c Mutual information analysis of the spike counts of each cell type to our 1-bit signal within early (0–5 ms) response (Kruskal–Wallis, H(2) = 9.88, p = 0.007; post-hoc t-tests: GFP− vs. GIN+: t(37) = −1.35, p = 0.190; GAD67+ vs. GIN+: t(41) = 2.37, p = 0.025; GFP− vs. GAD67+: t(36) = −3.01, p = 0.006*, * = tests significant at p ≤ 0.017 with Bonferroni correction). d Same analysis as (c) but restricting the analysis to only the later (5–50 ms) responses (Kruskal–Wallis, H(2) = 21.2, p ≤ 0.001; post-hoc t-tests: GFP− vs. GIN+: t(37) = −6.94, p ≤ 0.001*; GAD67+ vs. GIN+: t(41) = −2.26, p = 0.031; GFP− vs. GAD67+: t(36) = −3.49, p = 0.001*, * = tests significant at p ≤ 0.017 with Bonferroni correction).