Fig. 8: Different subtypes of interneurons carry different amounts of information in response to our rate encoding.

a Mutual information analysis of the average membrane potential of each cell type to our 1-bit signal within early (0–5 ms) response. Dotted lines indicate window of analysis, with greyed areas indicating what part of the response was analysed (Kruskal–Wallis, H(2) = 13.9, p ≤ 0.001; post-hoc t-tests: GFP− vs. GIN+: t(37) = −0.806, p = 0.425; GAD67+ vs. GIN+: t(40) = −4.17, p ≤ 0.001*; GFP− vs. GAD67+: t(35) = 3.48, p = 0.001*, * = tests significant at p ≤ 0.017 with Bonferroni correction). b Same analysis as (a) but restricting the analysis to only the later (5–50 ms) responses (One-way ANOVA, F(2,56) = 3.10, p = 0.053; post-hoc t-tests: GFP- vs. GIN+: t(37) = 0.266, p = 0.792; GAD67+ vs. GIN+: t(40) = −1.98, p = 0.054; GFP− vs. GAD67+: t(35) = 1.93, p = 0.062, * = tests significant at p ≤ 0.017 with Bonferroni correction). c Mutual information analysis of the spike counts of each cell type to our 1-bit signal within early (0–5 ms) response (One-way ANOVA, F(2,56) = 2.93, p = 0.066; post-hoc t-tests: GFP− vs. GIN+: t(37) = −2.04, p = 0.048; GAD67+ vs. GIN+: t(40) = −0.226, p = 0.778; GFP− vs. GAD67+: t(35) = −3.66, p = 0.002*, * = tests significant at p ≤ 0.017 with Bonferroni correction). d Same analysis as (c) but restricting the analysis to only the later (5–50 ms) responses (Kruskal–Wallis, H(2) = 30.5, p ≤ 0.001; post-hoc t-tests: GFP− vs. GIN+: t(37) = −6.42, p ≤ 0.001*; GAD67+ vs. GIN+: t(40) = −5.92, p ≤ 0.001*; GFP− vs. GAD67+: t(35) = −1.14, p = 0.324, * = tests significant at p ≤ 0.017 with Bonferroni correction).