Table 1 Ionizable lipid structure, pKa by ACD (theory), NMR, TNS, ZP,and pI by ZP.

From: Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

Lipid

Structure

pKa, ACD

pKa, NMR

pKa, TNS

pKa, ZP

n, ZP

pI, ZP

∆pKa NMR-TNS

∆pKa NMR -ZP

∆pKa TNS -ZP

DLin-KC2-DMA

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9.32

9.34

7.03

6.30

2.26

6.61

2.31

3.04

0.73

DLin-MC3-DMA

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9.37

9.47

6.57

5.77

1.69

5.93

2.9

3.7

0.80

DLin-DMA

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8.65

8.93

6.66

6.15

2.52

6.34

2.27

2.78

0.51

DODMA

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8.65

8.93

6.59

5.83

3.83

6.24

2.34

3.1

0.76

DODAP

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8.02

7.65

5.62

5.59

1.95

5.39

2.03

2.06

0.03

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