Fig. 7: GLP-grade LmCen−/− induce host pro-inflammatory immune response in human PBMCs. | Communications Biology

Fig. 7: GLP-grade LmCen−/− induce host pro-inflammatory immune response in human PBMCs.

From: Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis

Fig. 7

a Schematic representation of experiment plan to determine immune response of LmCen−/− in human PBMCs. b–d Scatter dot plots showing the levels (pg/ml) of pro-inflammatory (IFN-γ) (b) and anti-inflammatory (IL-10) (c) cytokine as well as IFN-γ/IL-10 ratio (d) in culture supernatant of PBMCs from Non-endemic region after 48 h of infection with LmCen−/− parasites by ELISA. Control group was left uninfected. Results (Mean ± SD) are representative of one experiment (p values were determined by Mann–Whitney two-tailed t test).

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