Fig. 2: Hindlimb unloading caused formaldehyde accumulation by affecting intracellular Ca2+ and FA metabolism in vivo.
From: Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading
a HU-induced the elevation in brain Ca2+ levels. (n = 6). HU hindlimb unloading. b, c Changes in the contents and activities of SSAO in the cerebellum of HU mice. (n = 6). SSAO semicarbazide-sensitive amine oxidase. d, e Changes in the contents and activities of brain FDH. (n = 6). FDH formaldehyde dehydrogenase. f Blood SSAO activity detected using a mouse SSAO kit. (n = 6). g SSAO (green) located in the cerebellum. DAPI (blue, a dye for nuclear). h Statistical analysis of cerebellar SSAO expression (n = 8). i Model of stress-induced FA generation. FA formaldehyde, FDH formaldehyde dehydrogenase, SSAO semicarbazide-sensitive amine oxidase. Error bars show the mean ± SEM; *p < 0.05, ***p < 0.001.
