Fig. 3: Functional annotation of the significantly altered secreted proteins.

Functional enrichment analyses of all significantly altered secreted proteins identified from label-free quantitative proteomics using nanoLC-ESI-LTQ-Orbitrap MS/MS (as detailed in Fig. 2 and Table 1) were performed in g:Profiler web server using g:GOSt tool (https://biit.cs.ut.ee/gprofiler/gost). Their biological processes (a), molecular functions (b), and cellular components (c) were visualized using Cytoscape (version 3.7.2).