Table 1 Summary of significantly altered proteins in COM-exposed macrophage secretome identified by nanoLC-ESI-LTQ-Orbitrap MS/MS.

From: Effects of secretome derived from macrophages exposed to calcium oxalate crystals on renal fibroblast activation

Protein name

Swiss-Prot ID

Intensity (x103 A.U.) (Mean ± SEM)

Ratio

P-value

Control

COM-exposed

(COM/Control)

40 S ribosomal protein S5

P46782

1068 ± 744

5881 ± 507

5.51

0.0118

Adenylyl cyclase-associated protein 1

Q01518

21326 ± 4921

37953 ± 1522

1.78

0.0248

Alpha-1B-glycoprotein

P04217

63867 ± 22042

8957 ± 1990

0.14

0.0287

Cathepsin Z

Q9UBR2

118146 ± 27416

42883 ± 4964

0.36

0.0282

Endoplasmic reticulum chaperone BiP

P11021

68106 ± 9978

19309 ± 875

0.28

0.0002

Flavin reductase (NADPH)

P30043

0 ± 0

5862 ± 774

#DIV/0!

0.0226

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

P62873

0 ± 0

6466 ± 852

#DIV/0!

0.0224

High mobility group protein B1

P09429

110802 ± 28122

23932 ± 1311

0.22

0.0075

InaD-like protein

Q8NI35

1111533 ± 226328

563389 ± 38071

0.51

0.0461

Inter-alpha-trypsin inhibitor heavy chain H2

P19823

151029 ± 35882

70060 ± 2323

0.46

0.0416

Leucine-rich alpha-2-glycoprotein

P02750

4250 ± 2872

13809 ± 1140

3.25

0.0481

Lysosomal acid lipase/cholesteryl ester hydrolase

P38571

1117 ± 1117

10383 ± 1373

9.30

0.0453

Lysosomal alpha-glucosidase

P10253

0 ± 0

6470 ± 1314

#DIV/0!

0.0002

Lysosome-associated membrane glycoprotein 1

P11279

366 ± 366

3206 ± 241

8.76

0.0029

Macrophage colony-stimulating factor 1 receptor

P07333

0 ± 0

23119 ± 2459

#DIV/0!

0.0064

Obg-like ATPase 1

Q9NTK5

1188 ± 788

8839 ± 619

7.44

0.0016

Polypyrimidine tract-binding protein 1

P26599

4541 ± 1966

12817 ± 852

2.82

0.0207

Proliferating cell nuclear antigen

P12004

34503 ± 14300

3524 ± 824

0.10

0.0486

Protein disulfide-isomerase A6

Q15084

5607 ± 848

10622 ± 201

1.89

0.0002

Semaphorin-4B

Q9NPR2

0 ± 0

549 ± 62

#DIV/0!

0.0090

Splicing factor, proline- and glutamine-rich

P23246

0 ± 0

4088 ± 569

#DIV/0!

0.0293

T-complex protein 1 subunit gamma

P49368

2181 ± 1115

7487 ± 561

3.43

0.0183

YTH domain-containing family protein 2

Q9Y5A9

55802 ± 13271

7254 ± 1229

0.13

0.0028

  1. A.U. arbitrary unit, #DIV/0! divided by zero (or newly present).
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