Fig. 6: CdGAP regulates G1 cell cycle progression and apoptosis. | Communications Biology

Fig. 6: CdGAP regulates G1 cell cycle progression and apoptosis.

From: CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis

Fig. 6

a Heatmap depicting cell-cycle checkpoint genes altered in CdGAP-depleted cells. b p21 mRNA levels in shCon (control) and shCdGAP PC-3 cells (n = 3). c Flow cytometry analysis of cell cycle distribution for CdGAP-depleted (shCdGAP) and control PC-3 cells. Cell cycle distribution is represented as the percentage of cells at each phase (n = 3). d Flow cytometry analysis of cell death in CdGAP-depleted (shCdGAP) and control PC-3 cells treated with doxorubicin (1, 2, and 5 µM) or vehicle (DMSO 0.05%) for 12 h. The percentage of cell population distribution (live, apoptosis, necrosis, late apoptosis) is represented (n = 3). Two-sample unpaired Student’s t test for comparison between two groups (shCon; shCdGAP). Error bars indicate SEM. ***p < 0.001; **p < 0.01; *p < 0.05.

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