Fig. 7: Loss of CdGAP delays subcutaneous tumor formation of PC-3 cells in vivo. | Communications Biology

Fig. 7: Loss of CdGAP delays subcutaneous tumor formation of PC-3 cells in vivo.

From: CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis

Fig. 7

Control (shCon) or CdGAP-depleted (shCdGAP) PC-3 cells were injected into the right flanks of 7-week-old nude mice. a Kaplan–Meier analysis of tumor-free mice using tumor initiation as an endpoint. Time of tumor initiation was defined as when a tumor reached a volume of 20 mm3. b Representative photographs of endpoint tumors that formed in control (n = 12) and shCdGAP (ndGAP) groups of mice. c Growth curves of subcutaneously formed tumors. Tumor volume was measured three times a week up to 34 days and is presented as the mean volume of each group (control = 12; shCdGAP = 11). Error bars indicate standard deviation (SD). d Tumor weight was measured at endpoint from control (n = 12) and shCdGAP (n = 11) groups of mice. Error bars indicate SEM. Two-sample unpaired Student’s t test for comparison between two groups (shCon; shCdGAP). **p < 0.001; *p < 0.05.

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