Fig. 6: Bintrafusp alfa responders have elevated MHC-I and MHC-II expression, and chemokine expression consistent with antitumor immunity. | Communications Biology

Fig. 6: Bintrafusp alfa responders have elevated MHC-I and MHC-II expression, and chemokine expression consistent with antitumor immunity.

From: Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma

Fig. 6

a Violin plots showing MHC-I and MHC-II subunit expression in the indicated UMAP clusters in A223 tumors responding (blue) and not responding (red) to bintrafusp alfa treatment. b Violin plots showing IL-33 expression in both A223 tumor cells and dividing tumor cells, separated by their responder (blue: responder, red: nonresponder) status. c Violin plots showing Stat1, CXCL9, CXCL10, CXCR3, and CCL5 expression in responder (blue) and nonresponder (red) tumors across all UMAP clusters. Violin plots show gene expression vertically on the y axis, and the binned cell count as the width on the x-axis.

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