Table 2 Neuroimaging regression analyses: results of between-group comparisons.

From: A role for GABA in the modulation of striatal and hippocampal systems under stress

Region

X mm

Y mm

Z mm

# Voxels

T

p

Regression with STR baseline GABA+

Main effect of practice

      

[Control-SCR]

      

 No suprathreshold clusters

      

[SCR-Control]

      

Hippocampus

−18

−24

−10

 31

3.13

0.031

Modulation by speed of performance

      

 No suprathreshold clusters

      

Regression with HC baseline GABA+

Main effect of practice

      

[Control-SCR]

      

 No suprathreshold clusters

      

[SCR-Control]

      

Hippocampus

28

−36

0

 30

2.98

0.031

Modulation by speed of performance

      

 No suprathreshold clusters

      

Regression with ΔGABA+ STR

Main effect of practice

      

[Control-SCR]

      

Hippocampus

−20

−14

−20

 79

3.42

0.015

[SCR-Control]

      

 No suprathreshold clusters

      

Modulation by speed of performance

      

[Control-SCR]

      

 No suprathreshold clusters

      

[SCR-Control]

      

Putamen

20

14

6

 218

3.39

0.016

 (extending to caudate)

      

Regression with ΔGABA+ HC

 No suprathreshold clusters

      
  1. Significance level set at pcorr < 0.05 corrected for multiple comparisons (FWE) over small volumes. All results survived Holm–Bonferroni correction for multiple testing. Due to missing fMRI data, one control participant was not included in the regressions with HC GABA+: N control = 23, N SCR = 22. Regressions with STR GABA+: N control = 26, N SCR = 26.
  2. ΔGABA+ post intervention/learning minus baseline, HC hippocampus, STR striatum, SCR stress cortisol responders.