Fig. 10: Genetic activation or disruption of Nrf2 does not affect colorectal adenoma formation in Gstp−/−: ApcMin/+ mice fed high-fat diet. | Communications Biology

Fig. 10: Genetic activation or disruption of Nrf2 does not affect colorectal adenoma formation in Gstp−/−: ApcMin/+ mice fed high-fat diet.

From: Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer

Fig. 10

Tumor multiplicity (a–d) and burden (e, f) in colons of 15-week-old Gstp−/−: ApcMin/+: Nrf2+/+: Keap1+/+ (WT, black circles), Gstp−/−: ApcMin/+: Nrf2−/−: Keap1+/+(Nrf2-KO, blue circles), Gstp−/−: ApcMin/+: Nrf2+/+: Keap1flox/flox (Keap1-KD, red circles), and Gstp−/−: ApcMin/+: Nrf2−/−: Keap1flox/flox (Nrf2-KO/Keap1-KD, cyan circles) mice (n = 53–62) that had been fed high-fat diet for 9 weeks. g mRNA levels for Bmp6 in livers of 15-week-old Gstp−/−: ApcMin/+: Nrf2+/+: Keap1+/+ (WT, black circles), Gstp−/−: ApcMin/+: Nrf2−/−: Keap1+/+(Nrf2-KO, blue circles), Gstp−/−: ApcMin/+: Nrf2+/+: Keap1flox/flox (Keap1-KD, red circles), and Gstp−/−: ApcMin/+: Nrf2−/−: Keap1flox/flox (Nrf2-KO/Keap1-KD, cyan circles) mice (n = 8) that had been fed high-fat diet for 9 weeks. Rplp0 was used as the reference gene. *p < 0.05 vs. WT.

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