Fig. 5: Tumor and peri-tumoral tissues have distinct metabolic states as revealed by LC-MS analysis.
From: Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
a, b Partial least square-discriminant analysis (PLS-DA) score plot from LC-MS data for aqueous metabolites, analyzed by: a C18pfp-based method (R2X = 71.9%, R2Y = 94% and Q2 = 89.3%) (a); and a behamide-based method (R2X = 55.8%, R2Y = 80.1% and Q2 = 74.7%) (b). In both cases, at least seven independent biological replicates of colon tissue from peri-tumorous (red) and tumorous (black) tissues were included. c, d Plots showing the individual metabolites driving the separation among the tissue types (loadings), for the C18pfp-based method (c) and the behamide-based method (d), with the variables (i.e., metabolites) represented in green circles, while the center for each genotype (peri-tumorous-DA(1), tumorous-DA(2)) is in blue.
