Fig. 2: Genome-wide association of genetic variants with onset of PI-IBS.
From: Campylobacter jejuni genotypes are associated with post-infection irritable bowel syndrome in humans
a ClonalFrame-ML phylogeny of PI-IBS isolates, with recombination masked114. Red leaves are isolates from PI-IBS patients and leaves with blue circles are from control patients. Common disease-associated clonal complexes (CCs) are highlighted. Interactive visualization is available on Microreact101: https://microreact.org/project/CampyIBS-CF. Matrix shows presence of variants most associated with IBS, which are labeled below (terminal, n = 5; simultaneous, n = 9; subsequent, n = 6). b Pangenome position of associated GWAS results (subsequent p-value < 0.05; n = 6,311; Table S4). Each circle represents a variant mapped to a position in the C. jejuni reference strain NCTC1116856 or inferred pangenome from this study (Supplementary Data 5). Variants with the strongest association (p-value < 0.000075; n = 6) from four genes with homologs in NCTC11168 are annotated (Cj0145:phoX, Cj0308:bioD, Cj0514:purQ, and Cj0894c:ispH). c Hot spots of associated variants. The number of associated variants per gene in NCTC11168 and the pangenome (any association p-value < 0.05). Genes with more than 100 associated variants are annotated, including four from the O-linked glycosylation locus. d Breakdown of associated variant types (core genome SNPs, core and accessory alleles, gene fission/fusions, accessory gene presence, and gene duplications; any association p-value < 0.05, raw data are available in Supplementary Data 6).
