Fig. 4: Theta delta ratios during the end of the delay period. | Communications Biology

Fig. 4: Theta delta ratios during the end of the delay period.

From: Altered theta rhythm and hippocampal-cortical interactions underlie working memory deficits in a hyperglycemia risk factor model of Alzheimer’s disease

Fig. 4

a, b Mean peri-event spectrograms for the hippocampus of control (a) and STZ (b) groups. Frequency is shown on the y-axis and time relative to trial start (TS) is on the x-axis. c Mean peri-event theta delta ratios for the hippocampus. TD ratio values on the y-axis and time relative to trial start is on the x-axis. Gray lines show control group value and magenta show STZ. Shaded error bars show standard error of the mean. d Mean running speed. Normalized running speed values are shown for the control (gray) and STZ (magenta) groups over the same time period as plots c, d. e Running F tests for TD ratios for the hippocampus. TD ratios from all trials were compared at each time step (500 ms) between the two groups with a single-factor ANOVA. F value is on the y-axis and time relative to trial start is on the x-axis. The red dotted lines show the level for significance at p < 0.05; Bonferroni corrected. Error bars = SEM.

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