Fig. 4: Characterisation of hamsters infected with low dose inocula of B.1.1.7 and HK-405. | Communications Biology

Fig. 4: Characterisation of hamsters infected with low dose inocula of B.1.1.7 and HK-405.

From: Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters

Fig. 4

a Body weight loss of hamsters infected with low dose inocula (10 PFU) of B.1.1.7 and HK-405. b Viral genome copies in nasal washes of the hamsters infected with B.1.1.7 and HK-405 collected on day 1 to 4 postinfection. Individual data points and mean ± SD are shown. c Histological score for lungs of infected hamsters on 4 dpi. d Representative images of H&E-stained hamster lung (left superior lobes) taken on 1 and 4 dpi. On 1 dpi, both viruses infected lung showed alveolar congestion. But on 4 dpi, diffuse alveolar infiltration, exudation and localized haemorrhage were observed after both viruses infection. Bronchiolar luminal cell debris (solid arrows) and vascular infiltration (open arrows) were also observed. Scale bars = 200 µM.

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