Fig. 3: The PLT variants affecting gene expression.

The Circular Manhattan plot shows genes identified in the cis-eQTL analyses whose expression is affected by the PLT variants (Supplementary Data 15). Only PLT variants affecting the expression of these genes are presented in the plot (Supplementary Data 2, Note ƚ). For variants, which affect expression of more than one gene, only the gene representing the strongest cis-eQTL (the largest effect size) is shown. Effector alleles are the same as in Supplementary Data 2. The yellow band: −log₁₀ of P value for association of the variants with PLT. Dots outside the yellow band represent the genetic effect sizes of the index PLT SNPs, with the blue dot color indicating PLT decrease and the red representing PLT increase (see Supplementary Data 2 for details). The green band: −log₁₀ of P value for association of the variants with cis-eQTLs. eQTL effects are shown as colored dots inside the green band. The dot size represents the effect size, and the color indicates the effect direction, where red is increase and blue is a decrease of gene expression. For scaling purposes, both PLT and cis-eQTL effects are expressed in standard deviation.