Fig. 5: Tumor mutation load is lower in more mature T-ALL subtypes.
From: A systematic analysis of genetic interactions and their underlying biology in childhood cancer
Sample tumor mutation load for each T-all subtype, with subtypes ordered (left to right) from early to late T-cell progenitor stage. Genes that were part of a candidate genetic interaction and that were significantly associated with a T-ALL subtype are depicted in the figure with their corresponding subtype and their MLA score (secondary vertical axis). Subtype ordering, coloring and assignment to genes were reproduced from Fig. 3 in ref. 31. Edges between genes represent “suspect” candidate genetic interactions found in T-ALL, defined as mutually exclusive gene pairs (shown in red) with one gene having an MLA score > 3 and together having a difference in MLA score > 3 or a co-occurring pair (shown in blue) with both genes having an MLA > 3. Source data underlying Fig. 5 can be found in Supplementary Data 2.
