Fig. 1: Variants reaching genome-wide significance in a meta-analysis of vertigo.
From: A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo
a A Manhattan plot showing six genome-wide significant loci. The horizontal lines represent the adjusted variant-class threshold (blue for missense variants [P ≤ 4.9 × 10−8] and orange for upstream variants [P ≤ 4.4 × 10−9]). Variants with a P value below their variant-class threshold are marked in green. The –log10P values (y-axis) are plotted for each variant against their chromosomal position (x-axis). Manhattan and quantile−quantile (Q-Q) plots66 for each dataset are shown in Supplementary Figs. 2 and 3. b Significance and odds ratios are shown for the combined analysis (see Fig. 3 and Supplementary Data 1 for association results for each dataset). Support for gene, where OMIM entry or animal studies support the implication of the genes in vestibular functions can be seen in detail in Table 1. MAF minor allele frequency, eQTL expression quantitative trait loci, OR odds ratio, CI confidence interval.
