Fig. 2: CCA-Like tumors are molecularly similar to CCA.
From: Genomic characterization of rare molecular subclasses of hepatocellular carcinoma
a Samples are ordered by subclass and sorted by key genomic alterations. Gene expression data is log2 transformed and median centered. Mutations (mut) are indicated by yellow/blue while wildtype (WT) are indicated by black. GISTIC thresholded values were used for copy number variation (CNV). bād Gene expression for hepatocyte markers (HNF4A and AFP) and cholangiocyte marker (SOX9) are shown per CCA/HCC group. Gene expression values represent the log2 transformed RSEMā+ā1 value. One-way ANOVA p-value is displayed. Boxes represent the IQR with the median represented by the bolded bar. Error bars represent Q1/Q3āĀ±ā1.5*IQR. e The median expression across the Bindea immune signatures was calculated and clustered by signatures. Samples were sorted by decreasing median expression across all signature and divided into high and low expression groups. PDL1 [range= 0, 8.5], PD1 [0, 11.1] and CTLA4 [0, 9.9] are represented as Log2(RSEMā+ā1 values). f Stacked bar plots represent the proportion of high and low immune expression group across the tumor classes. Fisher exact test p-values are shown for each comparison to HCC.
