Table 2 Correlation of immune gene expression and immunohistochemical staining of T-cell and macrophage infiltration in the tumors.

Gene name

Associated immune cell type

Correlation coefficient

p-value

q-value

CD8A

CD8⁺ T cells

0.94

1.4e-09

3.3e-07

CD160

Co-inhibition, T cell

0.86

2.9e-06

0.0002

CD274 or PDL1

Co-inhibition, APC; Co-inhibition, T cell

0.86

1.9e-06

0.0001

GZMA

Cytolytic activity

0.75

0.0002

0.003

CD2

Co-stimulation, T cell

0.7

0.001

0.010

ICOS

Co-stimulation, T cell

0.68

0.002

0.015

CLEC5A

Macrophages

0.67

0.002

0.016

TNFRSF4

Co-stimulation, T cell

0.65

0.003

0.020

KLRF1

NK cells

0.65

0.003

0.020

AHR

Type II IFN response

0.64

0.003

0.021

ISG20

Type I IFN response

0.63

0.004

0.022

HAVCR2

Co-inhibition, T cell

0.63

0.004

0.023

IRF8

pDCs

0.6

0.007

0.031

CXCR3

pDCs

0.59

0.008

0.035

TAP1

MHC Class I

0.58

0.009

0.036

CD79B

B cells

0.58

0.010

0.039

KDM6B

Neutrophils

0.56

0.012

0.046

TNFSF4

Co-stimulation, APC

−0.61

0.006

0.028

PRF1

Cytolytic activity

0.74

0.0001

0.008

SLAMF1

Co-stimulation, APC; Co-stimulation, T cell

0.71

0.0003

0.011

CD40 or OX40

Co-stimulation, APC

0.68

0.001

0.020

TNFRSF9

Co-stimulation, T cell

0.65

0.002

0.028

CXCR3

pDCs

0.62

0.003

0.042