Fig. 4: Single-cell RNA-sequencing of HLA-A24-restricted CMV-pp65-specific cytotoxic T-cells (CMV-CTL). | Communications Biology

Fig. 4: Single-cell RNA-sequencing of HLA-A24-restricted CMV-pp65-specific cytotoxic T-cells (CMV-CTL).

From: Features of repertoire diversity and gene expression in human cytotoxic T cells following allogeneic hematopoietic cell transplantation

Fig. 4

CMV-CTL clone counts and t-SNE plots in a Case14, b Case4, and c Case3. The actually-analyzed cell counts with combined information on gene expression and TCRβ-CDR3 were 972 (Case 14), 747 (Case 4), and 501 (Case 3) cells after apparently dying cells were deleted. Each dot represents a single cell and each color denotes the same individual clone. There was no robustly significant difference with a two-fold change and P < 0.05 in gene expression among the clones in each recipient, except for the TCR genes in all cases and GNLY and FXYD5 in Case3. The t-SNE clustering plots are shown after deleting apparently dying cells from Case3.

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