Fig. 7: Gene ontology (GO) enrichment analyses focusing on the immune system processes in HLA-A24-restricted CMV-pp65-specific cytotoxic T-cells (CMV-CTL) in the early phase of allo-HCT according to the CMV reactivation pattern in the subgroups of donor CMV serostatus. | Communications Biology

Fig. 7: Gene ontology (GO) enrichment analyses focusing on the immune system processes in HLA-A24-restricted CMV-pp65-specific cytotoxic T-cells (CMV-CTL) in the early phase of allo-HCT according to the CMV reactivation pattern in the subgroups of donor CMV serostatus.

From: Features of repertoire diversity and gene expression in human cytotoxic T cells following allogeneic hematopoietic cell transplantation

Fig. 7

a GO of the immune system processes and the shared genes derived from the top 500 differentially expressed genes (DEGs) with FDR < 0.1, focusing on the CMV-seropositive cohort alone. Each circle denotes an identified term with a P-value of <0.05 without the Bonferroni correction. The fused GO terms are shown. The same colors mean GO terms that belong to the same GO term-tree groups. The names of the leading GO terms are shown, based on the number of genes in each GO term-tree group. b The log-fold changes in the shared genes in the no-CMV (no-group, n = 5) and one-episode (one-group, n = 3) reactivation groups compared with the repeated CMV reactivation group (repeated group, n = 2). c GO of the immune system processes and the shared genes derived from the top 324 DEGs with FDR < 0.4, focusing on the CMV-seronegative cohort alone. Each circle denotes an identified term with a P-value of <0.05 without the Bonferroni correction. The fused GO terms are shown. The same colors mean GO terms that belong to the same GO term-tree groups. The names of the leading GO terms are shown based on the number of genes in each GO term-tree group in addition to the term of “T-cell costimulation”. d The log-fold changes in the shared genes in the no-CMV (no-group, n = 3) and one-episode (one-group, n = 4) reactivation groups compared with the repeated CMV reactivation group (repeated group, n = 4).

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