Table 2 Gene names and their actual or hypothetical functions based on GeneCards (The Human Gene Database, https://www.genecards.org/).
Gene symbol | Gene name | Functional explanation |
|---|---|---|
CCR2 | C-C Motif chemokine receptor 2 | a receptor for monocyte chemoattractant protein-1 |
CCR5 | C-C Motif chemokine receptor 5 | a regulator of granulocytic lineage proliferation |
CD160 | CD160 Molecule | the expression is closely associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity |
CD80 | CD80 Molecule | a membrane receptor that is activated by the binding of CD28 or CTLA-4 |
DDX5 | DEAD-Box helicase 5 | an RNA helicase |
DLG5 | Discs large MAGUK scaffold protein 5 | a regulator of the Hippo signaling pathway involved in regulating cell proliferation |
EPHB6 | EPH Receptor B6 | a kinase-defective receptor for members of the ephrin-B family that inhibits JNK activation and TCR-induced IL-2 secretion |
FCGR2A | Fc Fragment Of IgG receptor IIa | a low affinity receptor for immunoglobulin gamma, promoting phagocytosis and cellular responses against pathogens |
HBB | Hemoglobin subunit beta | an oxygen transporter |
HELLS | Helicase, lymphoid specific | a lymphoid specific helicase and regulator for the expansion or survival of lymphoid cells |
IL17RA | Interleukin 17 receptor A | a receptor of IL17 (a proinflammatory cytokine) secreted by activated T-lymphocytes |
IL18 | Interleukin 18 | a proinflammatory cytokine primarily involved in polarized T-helper 1 cell and NK cell immune responses |
IL1R1 | Interleukin 1 receptor Type 1 | a receptor of an important mediator, IL1, involved in many cytokine-induced immune and inflammatory responses |
IL6R | Interleukin 6 receptor | a subunit of the interleukin 6 (IL6) receptor complex) |
IL7R | Interleukin 7 receptor | a receptor for IL7 |
ISG20 | Interferon stimulated exonuclease gene 20 | an interferon-induced antiviral exoribonuclease |
LAX1 | Lymphocyte transmembrane adaptor 1 | a negative regulator of TCR-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells |
LGALS3 | Galectin 3 | a pre-mRNA splicing factor in acute inflammatory responses |
LILRB1 | Leukocyte immunoglobulin like receptor B1 | a member of the leukocyte immunoglobulin-like receptor family, transducing inhibitory signals and down-regulation of the immune response |
LILRB2 | Leukocyte immunoglobulin like receptor B2 | a member of the leukocyte immunoglobulin-like receptor family, transducing a negative signals and inhibiting stimulation of an immune response |
LY96 | Lymphocyte antigen 96 | a protein that is associated with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccharide |
MAD2L1 | Mitotic arrest deficient 2 Like 1 | a component of the mitotic spindle assembly checkpoint) |
RAD51AP1 | RAD51 Associated protein 1 | a structure-specific DNA-binding protein involved in DNA repair |
RSAD2 | Radical S-adenosyl methionine domain containing 2 | an interferon-inducible antiviral protein that belongs to the S-adenosyl-L-methionine (SAM) superfamily of enzymes |
S100A8 | S100 Calcium binding protein A8 | a regulator of inflammatory processes and immune response |
S100A9 | S100 Calcium binding protein A9 | a regulator of inflammatory processes and immune response |
SNAP25 | Synaptosome associated protein 25 | a regulator of neurotransmitter release |
TNF | Tumor necrosis factor | a multifunctional proinflammatory cytokine |
TNFRSF21 | TNF Receptor superfamily member 21 | a negative regulator of T-cell responses triggered by TCR stimulation |
TRAC | T Cell receptor alpha constant | a constant region of TCRα chain |
TUBB | Tubulin beta class I | a beta tubulin protein |
UBE2C | Ubiquitin conjugating enzyme E2 C | a member of the E2 ubiquitin-conjugating enzyme family |
VEGFA | Vascular endothelial growth factor A | a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth |
