Fig. 5: The combination map of N- and C-terminal hyper-motifs.
From: Connecting MHC-I-binding motifs with HLA alleles via deep learning
a The binding motif of an allele is a combination of an N-terminal and a C-terminal hyper-motif. After allocating all the alleles into the combination map, the cell color is determined by log10(number of alleles in the cell). In each cell with an allele number >10, the maximal HLA group and HLA groups with an allele number ≥25 or with a proportion (the allele number in the cell to the overall number of an allele group) >0.1 are listed. b The relation of a combination to its hyper-motifs. Four combinations are used as an example to illustrate the consistent signatures across different cells in the same column or row. The header column and header row consist of two N-terminal and two C-terminal clusters, respectively. Then, alleles of a cell, the combination of the N-terminal (column) and C-terminal (row) clusters, are used to generate the corresponding hyper-motif and allele signature. The color boxes are used to highlight the similar part of allele signatures. Source data are provided in Supplementary Data 8.
