Fig. 6: Characteristics of the HLA groups falling into multiple sub-motif clusters.
From: Connecting MHC-I-binding motifs with HLA alleles via deep learning
a Polymorphism on all 182 amino acids or the important positions of mono-cluster (group number = 44) or multi-cluster (group number = 27) HLA-groups. b AUC and AP of unobserved alleles grouped by mono-cluster (allele number = 7) or multi-cluster (allele number = 9) HLA-groups. c, d The hyper-motifs and highlighted allele signatures of the N-terminal sub-motif clusters of B*15 (c) and the C-terminal sub-motif clusters of B*56 (d). The box colored in gray is used to highlight the polymorphic sites. Boxplots depict the median value with a middle line, the 75th and 25th percentile upper and lower hinges, respectively, whiskers with 1.5× interquartile ranges, and points as outliers. P values (two-tailed independent t test) are shown as “ns” no significance and **P ≤ 0.01. Source data and details of the statistical analysis are provided in Supplementary Data 9 and 10.
