Fig. 2: Evolutionary changes induced by probiotics and their associations with experimental factors. | Communications Biology

Fig. 2: Evolutionary changes induced by probiotics and their associations with experimental factors.

From: Probiotic consumption influences universal adaptive mutations in indigenous human and mouse gut microbiota

Fig. 2

a A scatter plot shows the normalized number of SNVs (i.e., SNV number/sequencing depth of the target genome) induced by probiotic intervention for all included studies. Dashed lines connect the same probiotic strains in the animal experiment and human cohorts. The blue shadow represents the comparison of nSNVs produced by probiotics with that of the control group (NT-HNU082 and NT-Supherb Bio-25). b, c In human cohorts, alpha diversity indexes (Shannon and Simpson index) were calculated based on the species-level profile of SNVs induced by probiotic intake (P < 0.001). The shaded area indicates the full probability distribution of the variable. d In human cohorts, the genetic beta-diversity difference within and between studies was estimated based on the species-level SNV profile of native gut microbiomes. e No significant correlations between duration (R = 0.134, P = 0.205) and dose of probiotics (R = −0.112, P = 0.289) and the normalized number of SNVs induced by probiotics. f The study-dependent correlation between the Bray−Curtis distance of microbial species abundance profiles and the normalized number of SNVs induced by probiotics, including positive (AH1206 and HNU082), negative (LGG and Zhang), and uncorrelated (mixed probiotics). The source data for graphs are available as Supplementary Data 7 or FigShare (https://figshare.com/projects/Probiotic_consumption_influences_universal_adaptive_mutations_in_indigenous_human_and_mouse_gut_microbiota/122447).

Back to article page