Fig. 5: Neutralization analyses of animal immunized sera. | Communications Biology

Fig. 5: Neutralization analyses of animal immunized sera.

From: Ten emerging SARS-CoV-2 spike variants exhibit variable infectivity, animal tropism, and antibody neutralization

Fig. 5

Serially diluted serum preparations were incubated with pseudotyped SARS-CoV-2 variants as indicated. The remaining procedure is identical to the procedure in Fig. 5. ID50 ratios between the variants and the D614G reference strain are presented. a–d Dot plots of each serum sample against multiple variants. Data are presented as means ± SEMs. Dashed lines indicate the threshold of fourfold difference. E484K-carrying variants are marked in red. Reduced neutralization, folds compared with the D614G reference strain, is labeled at the bottom of each plot. e Heat map of mean ID50 ratio, compared with D614G. The shade of red indicates the degree of reduced neutralization (folds), as shown in the scale bar. f Neutralization ID50 values of different immunized serum samples against pseudotyped D614G virus. All experiments were repeated three times. Asterisks indicate statistical significance.

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