Fig. 1: Loss of Dyrk2 leads to multiple developmental abnormalities. | Communications Biology

Fig. 1: Loss of Dyrk2 leads to multiple developmental abnormalities.

From: Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient

Fig. 1

Dyrk2−/− mice exhibit multiple defects in craniofacial, hair follicle, and radial/limb development. a Lateral views of E18.5 embryos. Arrowhead; omphalocele. b Lateral views of H&E sections in E18.5 embryos. Arrowhead; omphalocele. c Lateral views of skeleton preps in E18.5 embryos. d Palatal shelves in E18.5 embryos. Red arrow; cleft palates. e H&E staining of palate in E18.5 embryos. Red arrowhead; cleft palates. T, tongue. f H&E staining of skin in E18.5 embryos. Numbers denote the stages of hair follicle morphogenesis. g Limb dysmorphology of E14.5 embryos. The red arrowhead; ectrodactyly. The yellow arrowhead; syndactyly. The white arrowhead; syndactyly and polydactyly. h Radial anomalies of E18.5 embryos. Black arrows; radial bones. Scale bar: 3 mm in a–d, h, 400 μm in e, 200 μm in f, 1 mm in g.

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