Fig. 3: Dyrk2−/− mice show reduced Foxf1 expression. | Communications Biology

Fig. 3: Dyrk2−/− mice show reduced Foxf1 expression.

From: Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient

Fig. 3

Dyrk2−/− mice display reduced expression of organogenesis associated genes. a, b Heatmap of genes related to transcription from GO analysis in E8.5 (a) and E10.5 (b) embryos. c Relative expression of genes related to developmental defect in E8.5 and 10.5 embryos (n = 3). d Relative expression of genes related to lung development in E10.5 embryos and E14.5 lungs (E10.5: n = 4; E14.5 lung: n = 3). e The representative foregut of E10.5 embryos from WT and Dyrk2−/− mice with the epithelium outlined by whole-mount E-cadherin immunostaining. Tr trachea, Es esophagus, Lu lung, St stomach, In intestine. Data are presented as the mean ± SD in c, d. *p < 0.05; **p < 0.01. Scale bar: 500 μm in e.

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