Fig. 4: Dyrk2−/− mice exhibit respiratory failure due to lung hypoplasia. | Communications Biology

Fig. 4: Dyrk2−/− mice exhibit respiratory failure due to lung hypoplasia.

From: Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient

Fig. 4

Dyrk2−/− mice exhibit sudden death soon after birth due to respiratory failure and lung hypoplasia. a Neonate lungs of WT and Dyrk2−/− mice. b Micro-CT analysis of the lung from P0 WT and Dyrk2−/− pups. The dashed line; the area of lung inflation. c H&E staining of the lungs in E18.5 embryos. d Optical image of E18.5 lung in WT and Dyrk2−/− embryos. Podoplanin (green), Pro-SP-C (green), VEGFR2 (green), and DAPI (blue). e Relative expression of genes related to AEC I and II makers in E18.5 lungs. Data are presented as the mean ± SD (n = 3; *p < 0.05). Scale bar: 200 μm (c) and 100 μm (d).

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