Table 2 List of up- and downregulated canonical host signaling pathways in Mtb-AG-infected rabbit lungs.

From: Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology

Canonical pathways

z-score (AG-vs-SC) and directiona

PTEN signaling

2.79 (upregulated)

RhoGDI signaling

2.65 (upregulated)

PPAR signaling

2.42 (upregulated)

Calcium signaling

2.40 (upregulated)

CD27 signaling in lymphocytes

2.36 (upregulated)

GAS signaling

1.70 (upregulated)

p38MAPK signaling

1.52 (upregulated)

Macropinocytosis signaling

−1.89 (downregulated)

ERK/MAPK signaling

−2.06 (downregulated)

Dendritic cell maturation

−3.01 (downregulated)

VEGF signaling

−3.05 (downregulated)

FcgRIIB signaling in B cells

−3.72 (downregulated)

GM-CSF Signaling

−4.22 (downregulated)

Th1 Pathway

−5.24 (downregulated)

  1. az-score is a measure of significance for the directionality of a biological function/pathway derived from the gene expression pattern. A positive z-score indicates activation/upregulation, and a negative z-score indicates suppression/downregulation of a biological function.
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