Table 1 AZD4785 detection in plasma-derived EVs.
Treatment regime | Plasma collection time after the last dose | |||||
|---|---|---|---|---|---|---|
72 h | 168 h | |||||
Plasma nM | EVs (fMol/106) | EVs plasma, nM | Plasma nM | EVs (fMol/106) | EVs plasma, nM | |
PBS | Not detected | NA | NA | Not detected | NA | NA |
AZD4785 125 mpk/wk | 12.48 | 0.07 | 0.85 | 4.28 | 0.03 | 0.11 |
AZD4785 250 mpk/wk | 18.72 | 0.07 | 0.80 | 6.57 | 0.02 | 0.10 |
