Fig. 2: Sexually dimorphic gene expression in quadriceps type IIB fibers.
From: Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle
a A total of 6978 genes whose CPM values were more than 10.0 in either of the two sexes (sham-operated males or females) were analyzed. Overall, 68 and 60 genes were found to be male enriched (M) and female enriched (F) by more than 2.0-fold, respectively. b, c Heatmaps of the male-enriched and female-enriched gene expressions in the 10 experimental mouse groups (see text and Supplementary Fig. 2) are shown. Color gradients correspond to the z-score as indicated at the right. d Results of principal component analysis of whole gene expression in the 10 groups are shown. PC1 and PC2 account for 17.5% and 15% of the percentage contribution to the variance, respectively. As indicated by closed ovals, the 10 groups are divided into three subgroups (SG1–SG3).
