Fig. 5: Local inference and annotation of introgression signals from snow sheep to Asiatic mouflon.
a Treemix analysis when m = 9. b, d f3-statistics and D-statistics of Asiatic mouflon (AMUF) with snow sheep (SNWS) pairs. Double dashed line marked as the range of threshold from -3 to 3. c Demographic diagram of admixture from snow sheep (O.nivicola) to Asiatic mouflon (O.orientalis). e Introgressed regions identified in the Asiatic mouflon genome. A modified f-statistic (fd) for (OUE,AMUF;SNWS,goat), π ratio (πw/πd, i.e., π of Asiatic mouflon/and π of all the domestic sheep) and FST between Asiatic mouflon and all the domestic sheep for 100-kb windows with 20-kb steps is plotted along the chromosomes. Each dot represents a 100-kb window. For f-statistic, green and blue dots above the red horizontal line correspond to the FDR 5% and FDR 1% significance level thresholds, respectively. The regions containing genes among three indexes (fd, π ratio, and \({F_{{{{\rm{ST}}}}}}\)) are plotted in red dots. For the π ratio (πw/πd) and FST, 340 domestic selection-related windows are plotted, and 62 verified candidate domestication genes are marked in the plot. Overlapped genes (n = 11) with f-statistic are marked in purple. f Venn diagram of overlapping genes (n = 11 for snow sheep and n = 13 for argali) between introgressed genes (n = 497 for snow sheep and n = 540 for argali) and candidate domestication genes (n = 62). g GO enrichment for 62 overlapped domestication genes with the previous studies. Source data d–g were presented in Supplementary Data 4 and Supplementary Data 5.
