Fig. 3: Identification of Torpor-specific Promoters and their Dynamics. | Communications Biology

Fig. 3: Identification of Torpor-specific Promoters and their Dynamics.

From: Integrative transcription start site analysis and physiological phenotyping reveal torpor-specific expression program in mouse skeletal muscle

Fig. 3

a Torpor-specific promoters were defined by the intersection of reversible and hypometabolic promoters. Up-regulated torpor-specific promoters (n = 226), which were CAGE clusters that were highly expressed exclusively during torpor, were at the intersection of the up-regulated reversible (n = 589) and hypometabolic promoters (n = 330). Down-regulated torpor-specific promoters (n = 61), which were CAGE clusters that were highly suppressed exclusively during torpor, were at the intersection of down-regulated reversible (n = 277) and hypometabolic promoters (n = 137). b, c Top five up-regulated (b) and down-regulated (c) torpor-specific promoters ordered according to the sum of the TPM change observed in the reversibility and hypometabolism experiments. Only promoters that had annotated downstream genes are shown. d Distribution of the SI of all of the mouse muscle promoters. An SI of 2 indicates a singleton-shaped CAGE TSS signal, and promoters with SI <−1 have a broad shape. e, f Distribution of the SI (e) or %GC (f) for torpor-specific promoters compared to all muscle promoters. The three horizontal lines inside the violin denote the 1st, 2nd, and 3rd quartile of the distribution from the upmost line.

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