Fig. 1: Matched ADRN and MES cell lines show prominent differences in telomere protein expression and localization. | Communications Biology

Fig. 1: Matched ADRN and MES cell lines show prominent differences in telomere protein expression and localization.

From: Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology

Fig. 1

a and b Western analysis of cell lineage, DNA sensing, and telomere-related factors in three matched ADRN and MES cell lines. The LA1-55N (ADRN) and LA1-5S (MES) pair, as well as the LA1-66N (ADRN) and LA1-6S (MES) pair, were both derived from LAN-1, a MYCN-amplified NB tumor. The SH-SY5Y (ADRN) and SH-EP1 (MES) pair was derived from a non-MYCN-amplified tumor. ADRN and MES cell line names are displayed in blue and green, respectively, in all figures in this study. c and d IF-FISH analysis of TRF1 and TRF2 in the indicated cell lines. Prominent examples of peri-nuclear staining of TRF2 in LA1-55N are marked with white arrows.

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