Fig. 6: Analysis of clinical tumor samples using a telomere- and cell lineage-related signature gene list. | Communications Biology

Fig. 6: Analysis of clinical tumor samples using a telomere- and cell lineage-related signature gene list.

From: Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology

Fig. 6

a The RNA levels (rank transformed) of a list of 29 telomere-, cell lineage- and immunity-related genes across 137 NB tumors with RNA-seq data were analyzed and clustered using PAM and displayed as a t-SNE plot. b The rank transformed RNA levels of signature genes across clustered NB tumor samples are displayed in Heatmap. c Kaplan–Meier overall survival curves for three clusters of patients with distinct gene expression profiles. d Kaplan–Meier overall survival and event free survival curves for patients with high TERT and low TERT expression.

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