Fig. 3: IMUNE-based discovery of IgG and IgM motifs in the SARS-CoV-2 humoral immune response. | Communications Biology

Fig. 3: IMUNE-based discovery of IgG and IgM motifs in the SARS-CoV-2 humoral immune response.

From: High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

Fig. 3

a Heatmap of IgG and IgM motif log-enrichment values for 579 COVID-19 samples and 1500 pre-pandemic controls. Inset highlights motifs with linear epitope maps to SARS-CoV-2. b Sensitivity and specificity of the SARS-CoV-2 IgG/IgM diagnostic classifier in NAT + subjects and pre-pandemic controls. Z-scores for each motif were summed to generate an IgG/IgM composite score. The maximum value for the IgG or IgM for each sample i shown. Samples above a cutoff of 25 are classified as positive. The sensitivity or specificity of the SERA panels for all COVID-19 cohorts and controls is shown above each column.

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