Fig. 4: Significantly different epitope signals are observed in mild, moderate, and severe cases of COVID-19. | Communications Biology

Fig. 4: Significantly different epitope signals are observed in mild, moderate, and severe cases of COVID-19.

From: High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

Fig. 4

a Comparison of SERA total IgG motif panel scores for severe (n = 447), moderate (n = 134), and mild (n = 170) cases based on motifs used in the diagnostic panel (Fig. 3). Colors indicate disease severity. b Severe, moderate, and mild cases of SARS-CoV-2 are clustered based on log-enrichment of the top 10 motifs identified by a t-test comparison of severe and mild patients. c Distribution of PIWAS values at SARS-CoV-2 furin cleavage site for severe, moderate, and mild cases. d Distribution of PIWAS values for the peak epitope in ORF8 for severe, moderate, and mild cases. e PIWAS tiling of individual samples on the entire ORF8 sequence. All p-values were calculated using outlier sum statistical test.

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