Fig. 3: Age-dependent anxiety- and depression-like behaviors in TgAPPsweOCN mice. | Communications Biology

Fig. 3: Age-dependent anxiety- and depression-like behaviors in TgAPPsweOCN mice.

From: Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence

Fig. 3

a, b OFT: Representative tracing images (a), and quantifications of total distance and center duration time (b) were shown. c, d EPMT: Representative tracing images (c), and quantifications of open arm duration time and entries (d) were shown. e LDT: Quantifications of the time spent in the light room and the number of transitions into the light room. f TST, g FST, and h SPT. In all these behavior tests, 6-MO and 12-MO control (LSL-APPswe) and TgAPPsweOCN mice (males) were examined. All quantification data were shown as mean ± SD (n = 10 mice). *p < 0.05, **p < 0.01, ***p < 0.001, Student’s t test.

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