Fig. 4: Age-dependent alterations in spatial learning and memory in TgAPPsweOCN mice. | Communications Biology

Fig. 4: Age-dependent alterations in spatial learning and memory in TgAPPsweOCN mice.

From: Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence

Fig. 4

a–c 3-MO control (LSL-APPswe) and TgAPPsweOCN male mice were subject to Morris water maze (MWM) (a, b) and Novel Object Recognition (NOR) (c) tests. d–f 6-MO control (LSL-APPswe) and TgAPPsweOCN male mice were subject to MWM (d, e) and NOR (f) tests. g–i 12-MO control (LSL-APPswe) and TgAPPsweOCN male mice were subject to MWM (g, h) and NOR (i) tests. In MWM tests, the latencies to reach the hidden platform during the training period were showed in a, d, and g; and the representative tracing images and quantification of time spent in target quadrant, platform crossing time, and swim speed were shown in b, e, and h. In NOR tests, the time spent with novel object per total time with both objects as the novel object preference was quantified, shown in c, f, and i. All values were presented as mean ± SD (n = 10 mice). *p < 0.05, one-way ANOVA followed by Tukey post hoc test was used in a, d, and g, and Student’s t test was used in b, c, e, f, h, and i.

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