Fig. 8: Increased cytokines and chemokines in TgAPPsweOCN serum samples. | Communications Biology

Fig. 8: Increased cytokines and chemokines in TgAPPsweOCN serum samples.

From: Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence

Fig. 8

a Representative images of serum L-Series label-multiplex antibody arrays of ~7-MO control and TgAPPsweOCN mice. b Volcano plots analysis of a. c Heat map of data in a. n = 4, significant difference was set at p < 0.05. d Elisa assays of serum IL1β and IL6 levels in ~7-MO control and TgAPPsweOCN mice. The data were presented as mean ± SD (n = 4 mice). *p < 0.05 by Student’s t test. e Comparison between this antibody array with secreted factors by RNA-seq of purified Tdtomato+ BMSCs. f Comparison of the changes (upregulated secreted proteins in Tg2576 over control mice) to those detected in TgAPPsweOCN mice.

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