Fig. 3: Antibody responses against SARS-CoV-2 variants.
From: Deep dissection of the antiviral immune profile of patients with COVID-19
We analyzed plasma samples from six patients with known antibody response against the native RBD protein for binding of their polyclonal IgG (left) and IgA (right) antibodies to RBD proteins harboring distinct mutations typically found in different SARS-CoV variants. Binding of polyclonal sera was significantly reduced compared to the wildtype RBD (dashed line) in the case of the RBD protein containing three different mutations K417N/E484K/N501Y. Bar graphs indicate medians and whiskers indicate 95% C.I. Asterisks indicate significance levels of p < 0.05 when compared to responses against the native RBD protein in the same patient using a Wilcoxon test.
